Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Identifieur interne : 000621 ( France/Analysis ); précédent : 000620; suivant : 000622Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Auteurs : Pamela Sklar [États-Unis] ; Stephan Ripke [États-Unis] ; Laura Scott [États-Unis] ; Ole Andreassen [Norvège] ; Sven Cichon [Allemagne] ; Nick Craddock [Royaume-Uni] ; Howard Edenberg [États-Unis] ; John Nurnberger [États-Unis] ; Marcella Rietschel [Allemagne] ; Douglas Blackwood [Royaume-Uni] ; Aiden Corvin [Irlande (pays)] ; Matthew Flickinger [États-Unis] ; Weihua Guan [États-Unis] ; Morten Mattingsdal [Norvège] ; Andrew Mcquillin [États-Unis] ; Phoenix Kwan [États-Unis] ; Thomas Wienker [Danemark] ; Mark Daly [États-Unis] ; Frank Dudbridge [Royaume-Uni] ; Peter Holmans [Royaume-Uni] ; Danyu Lin [États-Unis] ; Margit Burmeister [États-Unis] ; Tiffany Greenwood [États-Unis] ; Marian Hamshere [Royaume-Uni] ; Pierandrea Muglia [Italie] ; Erin Smith [États-Unis] ; Peter Zandi [États-Unis] ; Caroline Nievergelt [États-Unis] ; Rebecca Mckinney [États-Unis] ; Paul Shilling [États-Unis] ; Nicholas Schork [États-Unis] ; Cinnamon Bloss [États-Unis] ; Tatiana Foroud [États-Unis] ; Daniel Koller [États-Unis] ; Elliot Gershon [États-Unis] ; Chunyu Liu [États-Unis] ; Judith Badner [États-Unis] ; William Scheftner [États-Unis] ; William Lawson [États-Unis] ; Evaristus Nwulia [États-Unis] ; Maria Hipolito [États-Unis] ; William Coryell [États-Unis] ; John Rice [États-Unis] ; William Byerley [États-Unis] ; Francis Mcmahon [États-Unis] ; Thomas Schulze [Allemagne] ; Wade Berrettini [États-Unis] ; Falk Lohoff [États-Unis] ; James Potash [États-Unis] ; Pamela Mahon [États-Unis] ; Melvin Mcinnis [États-Unis] ; Sebastian Zöllner [États-Unis] ; Peng Zhang [États-Unis] ; David Craig [États-Unis] ; Szabocls Szelinger [États-Unis] ; Thomas Barrett [États-Unis] ; René Breuer [Allemagne] ; Sandra Meier [Allemagne] ; Jana Strohmaier [Allemagne] ; Stephanie Witt [Allemagne] ; Federica Tozzi [Italie] ; Anne Farmer [Royaume-Uni] ; Peter Mcguffin [Royaume-Uni] ; John Strauss [Canada] ; Wei Xu [Canada] ; James Kennedy [Canada] ; John Vincent [Canada] ; Keith Matthews [Royaume-Uni] ; Richard Day [Royaume-Uni] ; Manuel Ferreira [États-Unis] ; Colm O'Dushlaine [États-Unis] ; Roy Perlis [États-Unis] ; Soumya Raychaudhuri [États-Unis] ; Douglas Ruderfer [États-Unis] ; Phil Hyoun [États-Unis] ; Jordan Smoller [États-Unis] ; Jun Li [États-Unis] ; Devin Absher [États-Unis] ; Robert Thompson [États-Unis] ; Fan Guo Meng [États-Unis] ; Alan Schatzberg [États-Unis] ; William Bunney [États-Unis] ; Jack Barchas [États-Unis] ; Edward Jones [États-Unis] ; Stanley Watson [États-Unis] ; Richard Myers [États-Unis] ; Huda Akil [États-Unis] ; Michael Boehnke [États-Unis] ; Kim Chambert [États-Unis] ; Jennifer Moran [États-Unis] ; Ed Scolnick [États-Unis] ; Srdjan Djurovic [Norvège] ; Ingrid Melle [Norvège] ; Gunnar Morken [Norvège] ; Michael Gill [Royaume-Uni] ; Derek Morris [Irlande (pays)] ; Emma Quinn [États-Unis] ; Thomas Mühleisen [Allemagne] ; Franziska Degenhardt [Allemagne] ; Manuel Mattheisen [Danemark] ; Johannes Schumacher [Allemagne] ; Wolfgang Maier [Allemagne] ; Michael Steffens [Danemark] ; Peter Propping [Allemagne] ; Markus Nöthen [Allemagne] ; Adebayo Anjorin [États-Unis] ; Nick Bass [États-Unis] ; Hugh Gurling [États-Unis] ; Radhika Kandaswamy [États-Unis] ; Jacob Lawrence [États-Unis] ; Kevin Mcghee [Royaume-Uni] ; Andrew Mcintosh [Royaume-Uni] ; Alan Mclean [Royaume-Uni] ; Walter Muir [Royaume-Uni] ; Benjamin Pickard [Royaume-Uni] ; Gerome Breen [Royaume-Uni] ; David St Clair [Royaume-Uni] ; Sian Caesar [Royaume-Uni] ; Katherine Gordon-Smith [Royaume-Uni] ; Lisa Jones [Royaume-Uni] ; Christine Fraser [Royaume-Uni] ; Elaine Green [Royaume-Uni] ; Detelina Grozeva [Royaume-Uni] ; Ian Jones [Royaume-Uni] ; George Kirov [Royaume-Uni] ; Valentina Moskvina [Royaume-Uni] ; Ivan Nikolov [États-Unis] ; Michael O'Donovan [États-Unis] ; Michael Owen [Royaume-Uni] ; David Collier [Royaume-Uni] ; Amanda Elkin [Royaume-Uni] ; Richard Williamson [Royaume-Uni] ; Allan Young [Royaume-Uni] ; I Nicol Ferrier [Royaume-Uni] ; Kari Stefansson [Islande] ; Hreinn Stefansson [Islande] ; Porgeir Porgeirsson [Islande] ; Stacy Steinberg [Islande] ; Omar Gustafsson [Islande] ; Sarah Bergen [États-Unis] ; Vishwajit Nimgaonkar [États-Unis] ; Christina Hultman [Suède] ; Mikael Landén [Suède] ; Paul Lichtenstein [Suède] ; Patrick Sullivan [États-Unis] ; Martin Schalling [Suède] ; Urban Osby [Suède] ; Lena Backlund [Irlande (pays)] ; Louise Frisén [Suède] ; Niklas Langstrom [Suède] ; Stéphane Jamain [France] ; Marion Leboyer [France] ; Bruno Etain [France] ; Frank Bellivier [France] ; Hannes Petursson [Islande] ; Engilbert Sigur Sson [Islande] ; Bertram Müller-Mysok [France] ; Susanne Lucae [France] ; Markus Schwarz [Allemagne] ; Peter Schofield [Australie] ; Nick Martin [Australie] ; Grant Montgomery [Australie] ; Mark Lathrop [France] ; Högni Oskarsson [Islande] ; Michael Bauer [Allemagne] ; Adam Wright [Australie] ; Philip Mitchell [Australie] ; Martin Hautzinger [Allemagne] ; Andreas Reif [Allemagne] ; John Kelsoe [États-Unis] ; Shaun Purcell [États-Unis]Source :
- Nature Genetics [ 1061-4036 ] ; 2011-10.
Abstract
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P < 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 × 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.
Url:
DOI: 10.1038/ng.943
Affiliations:
- Allemagne, Australie, Canada, Danemark, France, Irlande (pays), Islande, Italie, Norvège, Royaume-Uni, Suède, États-Unis
- Iowa, Missouri (État), Pennsylvanie, Écosse, État de New York
- Iowa City, Ithaca (New York), Pittsburgh, Saint-Louis (Missouri), Édimbourg
- Université Cornell, Université Washington de Saint-Louis, Université d'Édimbourg, Université de Pittsburgh, Université de l'Iowa, École de médecine (Université Washington de Saint-Louis)
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Hal:inserm-00634944Le document en format XML
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type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Lin, Danyu" sort="Lin, Danyu" uniqKey="Lin D" first="Danyu" last="Lin">Danyu Lin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172312" status="INCOMING"> <orgName>Department of Biostatistics</orgName> <desc> <address> <addrLine>Chapel Hill, North Carolina</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-44261" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-44261" type="direct"><org type="institution" xml:id="struct-44261" status="VALID"> <orgName>The University of North 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xml:id="struct-300717" status="VALID"><orgName>University of California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Mckinney, Rebecca" sort="Mckinney, Rebecca" uniqKey="Mckinney R" first="Rebecca" last="Mckinney">Rebecca Mckinney</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172314" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300717" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300717" type="direct"><org type="institution" xml:id="struct-300717" 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California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Schork, Nicholas" sort="Schork, Nicholas" uniqKey="Schork N" first="Nicholas" last="Schork">Nicholas Schork</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172455" status="INCOMING"> <orgName>The Scripps Translational Science Institute and The Scripps Research Institute</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343644" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343644" type="direct"><org type="institution" xml:id="struct-343644" status="INCOMING"> <orgName>The Scripps Translational Science Institute and The Scripps Research Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Bloss, Cinnamon" sort="Bloss, Cinnamon" uniqKey="Bloss C" first="Cinnamon" last="Bloss">Cinnamon Bloss</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172317" status="INCOMING"> <orgName>The Scripps Translational Science Institute and Scripps Health</orgName> <desc> <address> <addrLine>La jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343614" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343614" type="direct"><org type="institution" xml:id="struct-343614" status="INCOMING"> <orgName>The Scripps Translational Science Institute and Scripps Health</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-128955" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Indianapolis, Indiana 46202</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-321989" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-321989" type="direct"><org type="institution" xml:id="struct-321989" status="INCOMING"> <orgName>Indiana University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Koller, Daniel" sort="Koller, Daniel" uniqKey="Koller D" first="Daniel" last="Koller">Daniel Koller</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-128955" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Indianapolis, Indiana 46202</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-321989" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-321989" type="direct"><org type="institution" xml:id="struct-321989" status="INCOMING"> <orgName>Indiana University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Gershon, Elliot" sort="Gershon, Elliot" uniqKey="Gershon E" first="Elliot" last="Gershon">Elliot Gershon</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172319" status="INCOMING"> <orgName>McKusick-Nathans Institute of Genetic Medicine</orgName> <desc> <address> <addrLine>733 N Broadway, Baltimore, MD 21205</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-309350" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309350" type="direct"><org type="institution" xml:id="struct-309350" status="INCOMING"> <orgName>Johns Hopkins University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172319" status="INCOMING"> <orgName>McKusick-Nathans Institute of Genetic Medicine</orgName> <desc> <address> 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Congress ParkwayChicago, IL 60612</addrLine> <country key="US"></country> </address> <ref type="url">https://www.rush.edu/</ref> </desc> </hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Lawson, William" sort="Lawson, William" uniqKey="Lawson W" first="William" last="Lawson">William Lawson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172321" status="INCOMING"> <orgName>Department of Psychiatry and Behavioral Sciences</orgName> <desc> <address> <addrLine>Washington, DC</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343616" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343616" type="direct"><org type="institution" xml:id="struct-343616" status="INCOMING"> <orgName>Howard University College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> 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[Mannhein]</orgName> <desc> <address> <addrLine>Mannheim</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.zi-mannheim.de/en/research/departments/genetic-epidemiology-psychiatry-e.html</ref> </desc> <listRelation> <relation active="#struct-236921" type="direct"></relation> <relation active="#struct-376876" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-236921" type="direct"><org type="institution" xml:id="struct-236921" status="VALID"> <orgName>Universität Heidelberg [Heidelberg]</orgName> <desc> <address> <addrLine> Seminarstraße 2, 69117 Heidelberg</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-heidelberg.de/</ref> </desc> </org></tutelle><tutelle active="#struct-376876" type="direct"><org type="institution" xml:id="struct-376876" status="INCOMING"> <orgName>Central Institute of Mental Health Mannheim</orgName> <desc> <address> <country key="FR"></country> </address> </desc> 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xml:id="struct-19908" status="VALID"> <orgName>Aarhus University [Aarhus]</orgName> <desc> <address> <addrLine>Nordre Ringgade 1 DK-8000 Aarhus C</addrLine> <country key="DK"></country> </address> <ref type="url">http://www.au.dk/en/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Danemark</country></affiliation></author><author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172256" status="INCOMING"> <orgName>Institute of Human Genetics</orgName> <desc> <address> <addrLine>Bonn</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-301322" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301322" type="direct"><org type="institution" xml:id="struct-301322" status="VALID"> <orgName>Université de Bonn</orgName> <desc> 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xml:id="struct-153548" status="VALID"> <orgName>The University of Alabama at Birmingham [ Birmingham]</orgName> <orgName type="acronym">UAB</orgName> <desc> <address> <addrLine>1720 2nd Ave S, Birmingham, AL 35233</addrLine> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Fraser, Christine" sort="Fraser, Christine" uniqKey="Fraser C" first="Christine" last="Fraser">Christine Fraser</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> 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<country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Jones, Ian" sort="Jones, Ian" uniqKey="Jones I" first="Ian" last="Jones">Ian Jones</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300799" type="direct"><org type="institution" xml:id="struct-300799" status="VALID"> <orgName>Medical Research Council</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303638" type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Kirov, George" sort="Kirov, George" uniqKey="Kirov G" first="George" last="Kirov">George Kirov</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation 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xml:id="struct-209475" status="VALID"> <orgName>Eberhard Karls Universität Tübingen</orgName> <desc> <address> <addrLine> Geschwister-Scholl-Platz 72074 Tübingen</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-tuebingen.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-15223" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Würzburg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-305900" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-305900" type="direct"><org type="institution" xml:id="struct-305900" status="INCOMING"><orgName>University of 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</org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00634944</idno><idno type="halId">inserm-00634944</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00634944</idno><idno type="url">http://www.hal.inserm.fr/inserm-00634944</idno><idno type="doi">10.1038/ng.943</idno><date when="2011-10">2011-10</date><idno type="wicri:Area/Hal/Corpus">000357</idno><idno type="wicri:Area/Hal/Curation">000357</idno><idno type="wicri:Area/Hal/Checkpoint">000399</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000399</idno><idno type="wicri:doubleKey">1061-4036:2011:Sklar P:large:scale:genome</idno><idno type="wicri:Area/Main/Merge">00A315</idno><idno type="wicri:Area/Main/Curation">009B70</idno><idno type="wicri:Area/Main/Exploration">009B70</idno><idno type="wicri:Area/France/Extraction">000621</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.</title><author><name sortKey="Sklar, Pamela" sort="Sklar, Pamela" uniqKey="Sklar P" first="Pamela" last="Sklar">Pamela Sklar</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-129536" status="INCOMING"> <orgName>Division of Psychiatric Genomics</orgName> <desc> <address> <addrLine>Department of Psychiatry, New York</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-305430" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-305430" type="direct"><org type="institution" xml:id="struct-305430" status="INCOMING"> <orgName>Mount Sinai School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Ripke, Stephan" sort="Ripke, Stephan" uniqKey="Ripke S" first="Stephan" last="Ripke">Stephan Ripke</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-129538" status="INCOMING"> <orgName>Center for Human Genetic Research</orgName> <desc> <address> <addrLine>Boston, Massachusetts</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-130467" type="direct"></relation> <relation active="#struct-374583" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-130467" type="direct"><org type="institution" xml:id="struct-130467" status="VALID"> <orgName>Harvard Medical School [Boston]</orgName> <orgName type="acronym">HMS</orgName> <desc> <address> <addrLine>25 Shattuck Street Boston, MA 02115</addrLine> <country key="US"></country> </address> <ref type="url">http://www.hms.harvard.edu</ref> </desc> </org></tutelle><tutelle active="#struct-374583" type="direct"><org type="institution" xml:id="struct-374583" status="INCOMING"> <orgName>Massachusetts General Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Scott, Laura" sort="Scott, Laura" uniqKey="Scott L" first="Laura" last="Scott">Laura Scott</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172097" status="INCOMING"> <orgName>Department of Biostatistics and Center for Statistical Genetics</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> <relation active="#struct-306744" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle><tutelle active="#struct-306744" type="direct"><org type="institution" xml:id="struct-306744" status="INCOMING"> <orgName>School of public health</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Andreassen, Ole" sort="Andreassen, Ole" uniqKey="Andreassen O" first="Ole" last="Andreassen">Ole Andreassen</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172098" status="INCOMING"> <orgName>Institute of Clinical Medicine</orgName> <desc> <address> <addrLine>Oslo</addrLine> <country 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<orgName>Department of Genetic Epidemiology in Psychiatry [Mannhein]</orgName> <desc> <address> <addrLine>Mannheim</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.zi-mannheim.de/en/research/departments/genetic-epidemiology-psychiatry-e.html</ref> </desc> <listRelation> <relation active="#struct-236921" type="direct"></relation> <relation active="#struct-376876" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-236921" type="direct"><org type="institution" xml:id="struct-236921" status="VALID"> <orgName>Universität Heidelberg [Heidelberg]</orgName> <desc> <address> <addrLine> Seminarstraße 2, 69117 Heidelberg</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-heidelberg.de/</ref> </desc> </org></tutelle><tutelle active="#struct-376876" type="direct"><org type="institution" xml:id="struct-376876" status="INCOMING"> <orgName>Central Institute of Mental Health Mannheim</orgName> <desc> <address> 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type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Lin, Danyu" sort="Lin, Danyu" uniqKey="Lin D" first="Danyu" last="Lin">Danyu Lin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172312" status="INCOMING"> <orgName>Department of Biostatistics</orgName> <desc> <address> <addrLine>Chapel Hill, North Carolina</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-44261" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-44261" type="direct"><org type="institution" xml:id="struct-44261" status="VALID"> <orgName>The University of North 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Scripps Health</orgName> <desc> <address> <addrLine>La jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343614" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343614" type="direct"><org type="institution" xml:id="struct-343614" status="INCOMING"> <orgName>The Scripps Translational Science Institute and Scripps Health</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Zandi, Peter" sort="Zandi, Peter" uniqKey="Zandi P" first="Peter" last="Zandi">Peter Zandi</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172318" status="INCOMING"> <orgName>Department of Mental Health</orgName> <desc> <address> <addrLine>Baltimore, Maryland</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation 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xml:id="struct-300717" status="VALID"><orgName>University of California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Mckinney, Rebecca" sort="Mckinney, Rebecca" uniqKey="Mckinney R" first="Rebecca" last="Mckinney">Rebecca Mckinney</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172314" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300717" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300717" type="direct"><org type="institution" xml:id="struct-300717" status="VALID"><orgName>University of California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Shilling, Paul" sort="Shilling, Paul" uniqKey="Shilling P" first="Paul" last="Shilling">Paul Shilling</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172314" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300717" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300717" type="direct"><org type="institution" xml:id="struct-300717" status="VALID"><orgName>University of California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Schork, Nicholas" sort="Schork, Nicholas" uniqKey="Schork N" first="Nicholas" last="Schork">Nicholas Schork</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172455" status="INCOMING"> <orgName>The Scripps Translational Science Institute and The Scripps Research Institute</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343644" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343644" type="direct"><org type="institution" xml:id="struct-343644" status="INCOMING"> <orgName>The Scripps Translational Science Institute and The Scripps Research Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Bloss, Cinnamon" sort="Bloss, Cinnamon" uniqKey="Bloss C" first="Cinnamon" last="Bloss">Cinnamon Bloss</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172317" status="INCOMING"> <orgName>The Scripps Translational Science Institute and Scripps Health</orgName> <desc> <address> <addrLine>La jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343614" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343614" type="direct"><org type="institution" xml:id="struct-343614" status="INCOMING"> <orgName>The Scripps Translational Science Institute and Scripps Health</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-128955" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Indianapolis, Indiana 46202</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-321989" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-321989" type="direct"><org type="institution" xml:id="struct-321989" status="INCOMING"> <orgName>Indiana University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Koller, Daniel" sort="Koller, Daniel" uniqKey="Koller D" first="Daniel" last="Koller">Daniel Koller</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-128955" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Indianapolis, Indiana 46202</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-321989" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-321989" type="direct"><org type="institution" xml:id="struct-321989" status="INCOMING"> <orgName>Indiana University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Gershon, Elliot" sort="Gershon, Elliot" uniqKey="Gershon E" first="Elliot" last="Gershon">Elliot Gershon</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172319" status="INCOMING"> <orgName>McKusick-Nathans Institute of Genetic Medicine</orgName> <desc> <address> <addrLine>733 N Broadway, Baltimore, MD 21205</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-309350" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309350" type="direct"><org type="institution" xml:id="struct-309350" status="INCOMING"> <orgName>Johns Hopkins University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172319" status="INCOMING"> <orgName>McKusick-Nathans Institute of Genetic Medicine</orgName> <desc> <address> <addrLine>733 N Broadway, Baltimore, MD 21205</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-309350" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309350" type="direct"><org type="institution" xml:id="struct-309350" status="INCOMING"> <orgName>Johns Hopkins University School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Badner, Judith" sort="Badner, Judith" uniqKey="Badner J" first="Judith" last="Badner">Judith Badner</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172319" status="INCOMING"> <orgName>McKusick-Nathans Institute of Genetic Medicine</orgName> <desc> <address> <addrLine>733 N Broadway, Baltimore, MD 21205</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation 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Congress ParkwayChicago, IL 60612</addrLine> <country key="US"></country> </address> <ref type="url">https://www.rush.edu/</ref> </desc> </hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Lawson, William" sort="Lawson, William" uniqKey="Lawson W" first="William" last="Lawson">William Lawson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172321" status="INCOMING"> <orgName>Department of Psychiatry and Behavioral Sciences</orgName> <desc> <address> <addrLine>Washington, DC</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343616" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343616" type="direct"><org type="institution" xml:id="struct-343616" status="INCOMING"> <orgName>Howard University College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Nwulia, Evaristus" sort="Nwulia, Evaristus" uniqKey="Nwulia E" first="Evaristus" last="Nwulia">Evaristus Nwulia</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172321" status="INCOMING"> <orgName>Department of Psychiatry and Behavioral Sciences</orgName> <desc> <address> <addrLine>Washington, DC</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-343616" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343616" type="direct"><org type="institution" xml:id="struct-343616" status="INCOMING"> <orgName>Howard University College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Hipolito, Maria" 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<country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Berrettini, Wade" sort="Berrettini, Wade" uniqKey="Berrettini W" first="Wade" last="Berrettini">Wade Berrettini</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172324" status="VALID"> <orgName>Department of Psychiatry [Philadelphia]</orgName> <desc> <address> <addrLine>University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-115889" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-115889" type="direct"><org type="institution" xml:id="struct-115889" status="VALID"><orgName>University of Pennsylvania [Philadelphia]</orgName><desc><address><addrLine>3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000</addrLine><country 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<orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172328" status="INCOMING"> <orgName>The Translational Genomics Research Institute</orgName> <desc> <address> 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[Mannhein]</orgName> <desc> <address> <addrLine>Mannheim</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.zi-mannheim.de/en/research/departments/genetic-epidemiology-psychiatry-e.html</ref> </desc> <listRelation> <relation active="#struct-236921" type="direct"></relation> <relation active="#struct-376876" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-236921" type="direct"><org type="institution" xml:id="struct-236921" status="VALID"> <orgName>Universität Heidelberg [Heidelberg]</orgName> <desc> <address> <addrLine> Seminarstraße 2, 69117 Heidelberg</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-heidelberg.de/</ref> </desc> </org></tutelle><tutelle active="#struct-376876" type="direct"><org type="institution" xml:id="struct-376876" status="INCOMING"> <orgName>Central Institute of Mental Health Mannheim</orgName> <desc> <address> <country key="FR"></country> </address> </desc> 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69117 Heidelberg</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-heidelberg.de/</ref> </desc> </org></tutelle><tutelle active="#struct-376876" type="direct"><org type="institution" xml:id="struct-376876" status="INCOMING"> <orgName>Central Institute of Mental Health Mannheim</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Witt, Stephanie" sort="Witt, Stephanie" uniqKey="Witt S" first="Stephanie" last="Witt">Stephanie Witt</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172259" status="VALID"> <orgName>Department of Genetic Epidemiology in Psychiatry [Mannhein]</orgName> <desc> <address> <addrLine>Mannheim</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.zi-mannheim.de/en/research/departments/genetic-epidemiology-psychiatry-e.html</ref> </desc> 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d'Édimbourg</orgName></affiliation></author><author><name sortKey="Breen, Gerome" sort="Breen, Gerome" uniqKey="Breen G" first="Gerome" last="Breen">Gerome Breen</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172461" status="INCOMING"> <orgName>Social, Genetic and Developmental Psychiatry Centre</orgName> <orgName type="acronym">SGDP</orgName> <desc> <address> <addrLine>The Institute of Psychiatry, De Crespigny Park Denmark Hill, London</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-327716" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-327716" type="direct"><org type="institution" xml:id="struct-327716" status="VALID"> <orgName>King‘s College London [London]</orgName> <desc> <address> <addrLine>Strand Campus, London WC2R 2LS</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.kcl.ac.uk</ref> </desc> 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xml:id="struct-153548" status="VALID"> <orgName>The University of Alabama at Birmingham [ Birmingham]</orgName> <orgName type="acronym">UAB</orgName> <desc> <address> <addrLine>1720 2nd Ave S, Birmingham, AL 35233</addrLine> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Fraser, Christine" sort="Fraser, Christine" uniqKey="Fraser C" first="Christine" last="Fraser">Christine Fraser</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> 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D" first="Detelina" last="Grozeva">Detelina Grozeva</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300799" type="direct"><org type="institution" xml:id="struct-300799" status="VALID"> <orgName>Medical Research Council</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303638" type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Jones, Ian" sort="Jones, Ian" uniqKey="Jones I" first="Ian" last="Jones">Ian Jones</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300799" type="direct"><org type="institution" xml:id="struct-300799" status="VALID"> <orgName>Medical Research Council</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303638" type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Kirov, George" sort="Kirov, George" uniqKey="Kirov G" first="George" last="Kirov">George Kirov</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-171643" status="INCOMING"> <orgName>Centre for Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation 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Neuropsychiatric Genetics and Genomics</orgName> <desc> <address> <addrLine>Henry Wellcome Building, School of Medicine, Heath Park, Cardiff</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-300799" type="direct"></relation> <relation active="#struct-303638" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300799" type="direct"><org type="institution" xml:id="struct-300799" status="VALID"> <orgName>Medical Research Council</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303638" type="direct"><org type="institution" xml:id="struct-303638" status="VALID"> <orgName>Cardiff University [Cardiff]</orgName> <desc> <address> <addrLine>CardiffWalesCF10 3AT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cardiff.ac.uk/</ref> </desc> 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</desc> </org></tutelle><tutelle active="#struct-420786" type="direct"><org type="institution" xml:id="struct-420786" status="VALID"> <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName> <orgName type="acronym">UPEC UP12</orgName> <desc> <address> <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-266797" status="VALID"> <idno type="RNSR">200919261B</idno> <idno type="IdRef">151294895</idno> <orgName>Institut Mondor de Recherche Biomédicale</orgName> <orgName type="acronym">IMRB</orgName> <desc> <address> <addrLine>8 rue du Général Sarrail 94010 Créteil</addrLine> 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</org></tutelle><tutelle active="#struct-420786" type="direct"><org type="institution" xml:id="struct-420786" status="VALID"> <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName> <orgName type="acronym">UPEC UP12</orgName> <desc> <address> <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-266797" status="VALID"> <idno type="RNSR">200919261B</idno> <idno type="IdRef">151294895</idno> <orgName>Institut Mondor de Recherche Biomédicale</orgName> <orgName type="acronym">IMRB</orgName> <desc> <address> <addrLine>8 rue du Général Sarrail 94010 Créteil</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.imrb.inserm.fr/</ref> </desc> <listRelation> <relation name="U955" active="#struct-303623" type="direct"></relation> <relation active="#struct-305148" type="direct"></relation> <relation active="#struct-420786" type="direct"></relation> </listRelation> <tutelles><tutelle name="U955" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-305148" type="direct"><org type="institution" xml:id="struct-305148" status="INCOMING"> <orgName>IFR10</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-420786" type="direct"><org type="institution" xml:id="struct-420786" status="VALID"> <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName> <orgName type="acronym">UPEC UP12</orgName> <desc> <address> <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Petursson, Hannes" sort="Petursson, Hannes" uniqKey="Petursson H" first="Hannes" last="Petursson">Hannes Petursson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172391" status="INCOMING"> <orgName>Division of Psychiatry</orgName> <desc> <address> <addrLine>Reykjavik</addrLine> <country key="IS"></country> </address> </desc> <listRelation> <relation active="#struct-300837" type="direct"></relation> <relation active="#struct-307718" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300837" type="direct"><org type="institution" xml:id="struct-300837" status="VALID"> <orgName>University of Iceland [Reykjavik]</orgName> <desc> <address> <addrLine>Sæmundargata 2101 Reykjavík</addrLine> <country key="IS"></country> </address> <ref type="url">http://english.hi.is/</ref> </desc> </org></tutelle><tutelle active="#struct-307718" type="direct"><org type="institution" xml:id="struct-307718" status="INCOMING"> <orgName>Landspitali University Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Islande</country></affiliation></author><author><name sortKey="Sigur Sson, Engilbert" sort="Sigur Sson, Engilbert" uniqKey="Sigur Sson E" first="Engilbert" last="Sigur Sson">Engilbert Sigur Sson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172391" status="INCOMING"> <orgName>Division of Psychiatry</orgName> <desc> <address> <addrLine>Reykjavik</addrLine> <country key="IS"></country> </address> </desc> <listRelation> <relation active="#struct-300837" type="direct"></relation> <relation active="#struct-307718" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300837" type="direct"><org type="institution" xml:id="struct-300837" status="VALID"> <orgName>University of Iceland [Reykjavik]</orgName> <desc> <address> <addrLine>Sæmundargata 2101 Reykjavík</addrLine> <country key="IS"></country> </address> <ref type="url">http://english.hi.is/</ref> </desc> </org></tutelle><tutelle active="#struct-307718" type="direct"><org type="institution" xml:id="struct-307718" status="INCOMING"> <orgName>Landspitali University Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Islande</country></affiliation></author><author><name sortKey="Muller Mysok, Bertram" sort="Muller Mysok, Bertram" uniqKey="Muller Mysok B" first="Bertram" last="Müller-Mysok">Bertram Müller-Mysok</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172392" status="INCOMING"> <orgName>Max Planck Institute of Psychiatry</orgName> <desc> <address> <addrLine>Munich</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-323510" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-323510" type="direct"><org type="institution" xml:id="struct-323510" status="INCOMING"> <orgName>Max Planck Institute of Psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172392" status="INCOMING"> <orgName>Max Planck Institute of Psychiatry</orgName> <desc> <address> <addrLine>Munich</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-323510" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-323510" type="direct"><org type="institution" xml:id="struct-323510" status="INCOMING"> <orgName>Max Planck Institute of Psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-151520" status="INCOMING"> <orgName>Psychiatric Center Nordbaden</orgName> <desc> <address> <addrLine>Wiesloch</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-343622" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343622" type="direct"><org type="institution" xml:id="struct-343622" status="INCOMING"> <orgName>Psychiatric Center Nordbaden</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Schofield, Peter" sort="Schofield, Peter" uniqKey="Schofield P" first="Peter" last="Schofield">Peter Schofield</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-99698" status="VALID"> <orgName>Prince of Wales Medical Research Institute</orgName> <desc> <address> <addrLine>Barker Street Randwick NSW 2031</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.neura.edu.au/</ref> </desc> <listRelation> <relation active="#struct-74661" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-74661" type="direct"><org type="institution" xml:id="struct-74661" status="VALID"> <orgName>University of New South Wales [Sydney]</orgName> <desc> <address> <addrLine>High StKensington, Sydney, NSW 2052</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unsw.edu.au/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country></affiliation></author><author><name sortKey="Martin, Nick" sort="Martin, Nick" uniqKey="Martin N" first="Nick" last="Martin">Nick Martin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172333" status="INCOMING"> <orgName>Queensland Institute of Medical Research</orgName> <desc> <address> <addrLine>Brisbane</addrLine> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-332582" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-332582" type="direct"><org type="institution" xml:id="struct-332582" status="INCOMING"> <orgName>Queensland Institute of Medical Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country></affiliation></author><author><name sortKey="Montgomery, Grant" sort="Montgomery, Grant" uniqKey="Montgomery G" first="Grant" last="Montgomery">Grant Montgomery</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172333" status="INCOMING"> <orgName>Queensland Institute of Medical Research</orgName> <desc> <address> <addrLine>Brisbane</addrLine> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-332582" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-332582" type="direct"><org type="institution" xml:id="struct-332582" status="INCOMING"> <orgName>Queensland Institute of Medical Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31446" status="VALID"> <orgName>Centre National de Génotypage</orgName> <orgName type="acronym">CNG</orgName> <desc> <address> <addrLine>Centre National de Génotypage 2 rue Gaston Crémieux CP5721 91057 EVRY Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cng.fr</ref> </desc> <listRelation> <relation name="DSV/IG" active="#struct-300016" type="direct"></relation> </listRelation> <tutelles><tutelle name="DSV/IG" active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID"> <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName> <orgName type="acronym">CEA</orgName> <desc> <address> <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cea.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Oskarsson, Hogni" sort="Oskarsson, Hogni" uniqKey="Oskarsson H" first="Högni" last="Oskarsson">Högni Oskarsson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172396" status="INCOMING"> <orgName>Therapeia</orgName> <desc> <address> <addrLine>Reykjavik</addrLine> <country key="IS"></country> </address> </desc> <listRelation> <relation active="#struct-343623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343623" type="direct"><org type="institution" xml:id="struct-343623" status="INCOMING"> <orgName>Therapeia</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Islande</country></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172397" status="INCOMING"> <orgName>Department of Psychiatry and Psychotherapy, ENBREC Group</orgName> <desc> <address> <addrLine>Dresden</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-343624" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-343624" type="direct"><org type="institution" xml:id="struct-343624" status="INCOMING"> <orgName>University Hospital Carl Gustav Carus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172398" status="INCOMING"> <orgName>School of Psychiatry</orgName> <desc> <address> <addrLine>Sydney, New South Wales</addrLine> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-74661" type="direct"></relation> <relation active="#struct-343625" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-74661" type="direct"><org type="institution" xml:id="struct-74661" status="VALID"> <orgName>University of New South Wales [Sydney]</orgName> <desc> <address> <addrLine>High StKensington, Sydney, NSW 2052</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unsw.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-343625" type="direct"><org type="institution" xml:id="struct-343625" status="INCOMING"> <orgName>Black Dog Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country></affiliation></author><author><name sortKey="Mitchell, Philip" sort="Mitchell, Philip" uniqKey="Mitchell P" first="Philip" last="Mitchell">Philip Mitchell</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172398" status="INCOMING"> <orgName>School of Psychiatry</orgName> <desc> <address> <addrLine>Sydney, New South Wales</addrLine> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-74661" type="direct"></relation> <relation active="#struct-343625" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-74661" type="direct"><org type="institution" xml:id="struct-74661" status="VALID"> <orgName>University of New South Wales [Sydney]</orgName> <desc> <address> <addrLine>High StKensington, Sydney, NSW 2052</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unsw.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-343625" type="direct"><org type="institution" xml:id="struct-343625" status="INCOMING"> <orgName>Black Dog Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-165979" status="INCOMING"> <orgName>Department of Clinical and Developmental Psychology</orgName> <desc> <address> <addrLine>Institute of Psychology, Tubingen</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-209475" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-209475" type="direct"><org type="institution" xml:id="struct-209475" status="VALID"> <orgName>Eberhard Karls Universität Tübingen</orgName> <desc> <address> <addrLine> Geschwister-Scholl-Platz 72074 Tübingen</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-tuebingen.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-15223" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Würzburg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-305900" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-305900" type="direct"><org type="institution" xml:id="struct-305900" status="INCOMING"><orgName>University of Würzburg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kelsoe, John" sort="Kelsoe, John" uniqKey="Kelsoe J" first="John" last="Kelsoe">John Kelsoe</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172314" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>La Jolla, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300717" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300717" type="direct"><org type="institution" xml:id="struct-300717" status="VALID"><orgName>University of California [San Diego]</orgName><orgName type="acronym">UC San Diego</orgName><desc><address><addrLine>9500 Gilman Dr., La Jolla, CA 92093 USA</addrLine><country key="US"></country></address><ref type="url">https://ucsd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Purcell, Shaun" sort="Purcell, Shaun" uniqKey="Purcell S" first="Shaun" last="Purcell">Shaun Purcell</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-172096" status="INCOMING"> <orgName>Stanley Center for Psychiatric Research</orgName> <desc> <address> <addrLine>Cambridge, Massachusetts</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-307648" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-307648" type="direct"><org type="institution" xml:id="struct-307648" status="INCOMING"> <orgName>Broad Institute of MIT and Harvard</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author></analytic><idno type="DOI">10.1038/ng.943</idno><series><title level="j">Nature Genetics</title><idno type="ISSN">1061-4036</idno><imprint><date type="datePub">2011-10</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P < 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 × 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>France</li><li>Irlande (pays)</li><li>Islande</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Iowa</li><li>Missouri (État)</li><li>Pennsylvanie</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Iowa City</li><li>Ithaca (New York)</li><li>Pittsburgh</li><li>Saint-Louis (Missouri)</li><li>Édimbourg</li></settlement><orgName><li>Université Cornell</li><li>Université Washington de Saint-Louis</li><li>Université d'Édimbourg</li><li>Université de Pittsburgh</li><li>Université de l'Iowa</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Sklar, Pamela" sort="Sklar, Pamela" uniqKey="Sklar P" 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Niklas" sort="Langstrom, Niklas" uniqKey="Langstrom N" first="Niklas" last="Langstrom">Niklas Langstrom</name><name sortKey="Lichtenstein, Paul" sort="Lichtenstein, Paul" uniqKey="Lichtenstein P" first="Paul" last="Lichtenstein">Paul Lichtenstein</name><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Osby">Urban Osby</name><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name></country><country name="France"><noRegion><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name></noRegion><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><name sortKey="Muller Mysok, Bertram" sort="Muller Mysok, Bertram" uniqKey="Muller Mysok B" first="Bertram" last="Müller-Mysok">Bertram Müller-Mysok</name></country><country name="Australie"><noRegion><name sortKey="Schofield, Peter" sort="Schofield, Peter" uniqKey="Schofield P" first="Peter" last="Schofield">Peter Schofield</name></noRegion><name sortKey="Martin, Nick" sort="Martin, Nick" uniqKey="Martin N" first="Nick" last="Martin">Nick Martin</name><name sortKey="Mitchell, Philip" sort="Mitchell, Philip" uniqKey="Mitchell P" first="Philip" last="Mitchell">Philip Mitchell</name><name sortKey="Montgomery, Grant" sort="Montgomery, Grant" uniqKey="Montgomery G" first="Grant" last="Montgomery">Grant Montgomery</name><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
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